Amphetamine and Benzphetamine interaction
Amphetamine and Benzphetamine: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Amphetamine (Dyanavel XR) label · effective 2026-02-24
Hypersensitivity reactions such as angioedema and anaphylactic reactions have been reported in patients treated with other amphetamine products [ see Adverse Reactions (6) ] .
Tricyclic Antidepressants Clinical Impact May enhance the activity of tricyclic or sympathomimetic agents causing striking and sustained increases in the concentration of d- amphetamine in the brain; cardiovascular effects can be potentiated.
From the Benzphetamine (Benzphetamine Hydrochloride) label · effective 2026-06-18
Amphetamines have been shown to be teratogenic and embryotoxic in mammals at high multiples of the human dose.
Benzphetamine Hydrochloride Tablets should not be used concomitantly with other CNS stimulants.
Benzphetamine hydrochloride tablets should not be used concomitantly with other CNS stimulants.
Amphetamines may decrease the hypotensive effect of antihypertensives.
Amphetamines may enhance the effects of tricyclic antidepressants.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.