Benzphetamine interactions

Benzphetamine (Didrex, Regimex), a CNS stimulant has 236 documented interactions across the FDA labels and fact sheets we index: 58 major, 157 moderate, 21 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

Interactions from the label

Major interactions (58)

  • Albuterolbeta-adrenergic agonistMajor

    CONTRAINDICATIONS Benzphetamine Hydrochloride Tablets are contraindicated in patients with advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, hyperthyroidism, known hypersensitivity or idiosyncrasy to sympathomimetic amines, and glaucoma. (Benzphetamine label, Contraindications)

  • AmphetamineCNS stimulantMajor

    Amphetamines have been shown to be teratogenic and embryotoxic in mammals at high multiples of the human dose. (Benzphetamine label, Contraindications)

  • Amphetamines have been shown to be teratogenic and embryotoxic in mammals at high multiples of the human dose. (Benzphetamine label, Contraindications)

  • Arformoterolbeta-adrenergic agonistMajor

    CONTRAINDICATIONS Benzphetamine Hydrochloride Tablets are contraindicated in patients with advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, hyperthyroidism, known hypersensitivity or idiosyncrasy to sympathomimetic amines, and glaucoma. (Benzphetamine label, Contraindications)

  • ArmodafinilCNS stimulantMajor

    Benzphetamine Hydrochloride Tablets should not be used concomitantly with other CNS stimulants. (Benzphetamine label, Contraindications)

  • CONTRAINDICATIONS Benzphetamine Hydrochloride Tablets are contraindicated in patients with advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, hyperthyroidism, known hypersensitivity or idiosyncrasy to sympathomimetic amines, and glaucoma. (Benzphetamine label, Contraindications)

  • Budesonide and formoterolcorticosteroidMajor

    CONTRAINDICATIONS Benzphetamine Hydrochloride Tablets are contraindicated in patients with advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, hyperthyroidism, known hypersensitivity or idiosyncrasy to sympathomimetic amines, and glaucoma. (Benzphetamine label, Contraindications)

  • Benzphetamine Hydrochloride Tablets should not be used concomitantly with other CNS stimulants. (Benzphetamine label, Contraindications)

  • Benzphetamine Hydrochloride Tablets should not be used concomitantly with other CNS stimulants. (Benzphetamine label, Contraindications)

  • Benzphetamine Hydrochloride Tablets should not be used concomitantly with other CNS stimulants. (Benzphetamine label, Contraindications)

  • Benzphetamine Hydrochloride Tablets should not be used concomitantly with other CNS stimulants. (Benzphetamine label, Contraindications)

  • Chloroprocainelocal anestheticMajor

    Vasopressors should not be used in the presence of ergot-type oxytocic drugs, since a severe persistent hypertension may occur. (Chloroprocaine label, Warnings)

  • Cocainelocal anestheticMajor

    WARNING: ABUSE AND DEPENDENCE CNS stimulants, including cocaine hydrochloride, have a high potential for abuse and dependence. (Cocaine label, Boxed warning)

  • DexmethylphenidateCNS stimulantMajor

    Benzphetamine Hydrochloride Tablets should not be used concomitantly with other CNS stimulants. (Benzphetamine label, Contraindications)

  • DextroamphetamineCNS stimulantMajor

    Benzphetamine Hydrochloride Tablets should not be used concomitantly with other CNS stimulants. (Benzphetamine label, Contraindications)

  • DiethylpropionCNS stimulantMajor

    Benzphetamine Hydrochloride Tablets should not be used concomitantly with other CNS stimulants. (Benzphetamine label, Contraindications)

  • DronabinolcannabinoidMajor

    Avoid concomitant use of other drugs that are also associated with similar cardiac effects (e.g., amphetamines, other sympathomimetic agents, atropine, amoxapine, scopolamine, antihistamines, other anticholinergic agents, amitriptyline, desipramine, other tricyclic antidepressants). (Dronabinol label, Warnings and precautions)

  • EpinephrinesympathomimeticMajor

    CONTRAINDICATIONS Benzphetamine Hydrochloride Tablets are contraindicated in patients with advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, hyperthyroidism, known hypersensitivity or idiosyncrasy to sympathomimetic amines, and glaucoma. (Benzphetamine label, Contraindications)

  • Ergotamine and caffeineergot alkaloidMajor

    Benzphetamine Hydrochloride Tablets should not be used concomitantly with other CNS stimulants. (Benzphetamine label, Contraindications)

  • Fluticasone and salmeterolcorticosteroidMajor

    CONTRAINDICATIONS Benzphetamine Hydrochloride Tablets are contraindicated in patients with advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, hyperthyroidism, known hypersensitivity or idiosyncrasy to sympathomimetic amines, and glaucoma. (Benzphetamine label, Contraindications)

  • Formoterolbeta-adrenergic agonistMajor

    CONTRAINDICATIONS Benzphetamine Hydrochloride Tablets are contraindicated in patients with advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, hyperthyroidism, known hypersensitivity or idiosyncrasy to sympathomimetic amines, and glaucoma. (Benzphetamine label, Contraindications)

  • Imipraminetricyclic antidepressantMajor

    Avoid the use of preparations, such as decongestants and local anesthetics, that contain any sympathomimetic amine (e.g., epinephrine, norepinephrine), since it has been reported that tricyclic antidepressants can potentiate the effects of catecholamines. (Imipramine label, Drug interactions)

  • Ipratropium and albuterolanticholinergicMajor

    CONTRAINDICATIONS Benzphetamine Hydrochloride Tablets are contraindicated in patients with advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, hyperthyroidism, known hypersensitivity or idiosyncrasy to sympathomimetic amines, and glaucoma. (Benzphetamine label, Contraindications)

  • IsoniazidantibioticMajor

    Hypertensive crises have resulted when sympathomimetic amines have been used concomitantly or within 14 days following use of monoamine oxidase inhibitors. (Benzphetamine label, Contraindications)

  • Isoproterenolbeta-adrenergic agonistMajor

    CONTRAINDICATIONS Benzphetamine Hydrochloride Tablets are contraindicated in patients with advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, hyperthyroidism, known hypersensitivity or idiosyncrasy to sympathomimetic amines, and glaucoma. (Benzphetamine label, Contraindications)

  • Levalbuterolbeta-adrenergic agonistMajor

    CONTRAINDICATIONS Benzphetamine Hydrochloride Tablets are contraindicated in patients with advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, hyperthyroidism, known hypersensitivity or idiosyncrasy to sympathomimetic amines, and glaucoma. (Benzphetamine label, Contraindications)

  • Levothyroxine and liothyroninethyroid hormoneMajor

    Larger doses may produce serious or even life-threatening manifestations of toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects. (Levothyroxine and liothyronine label, Boxed warning)

  • LinezolidantibioticMajor

    Hypertensive crises have resulted when sympathomimetic amines have been used concomitantly or within 14 days following use of monoamine oxidase inhibitors. (Benzphetamine label, Contraindications)

  • Liothyroninethyroid hormoneMajor

    • Larger doses may produce serious or even life-threatening manifestations of toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects [see Adverse Reactions (6) , Drug Interactions (7.7) , and Overdosage (10) ] . (Liothyronine label, Boxed warning)

  • LisdexamfetamineCNS stimulantMajor

    Benzphetamine Hydrochloride Tablets should not be used concomitantly with other CNS stimulants. (Benzphetamine label, Contraindications)

  • Mepivacainelocal anestheticMajor

    Mepivacaine with epinephrine or other vasopressors should not be used concomitantly with ergot-type oxytocic drugs, because a severe persistent hypertension may occur. (Mepivacaine label, Warnings)

  • MethamphetamineCNS stimulantMajor

    Benzphetamine Hydrochloride Tablets should not be used concomitantly with other CNS stimulants. (Benzphetamine label, Contraindications)

  • Methylene blueMAO inhibitorMajor

    Hypertensive crises have resulted when sympathomimetic amines have been used concomitantly or within 14 days following use of monoamine oxidase inhibitors. (Benzphetamine label, Contraindications)

  • MethylphenidateCNS stimulantMajor

    Benzphetamine Hydrochloride Tablets should not be used concomitantly with other CNS stimulants. (Benzphetamine label, Contraindications)

  • Mirabegronbeta-adrenergic agonistMajor

    CONTRAINDICATIONS Benzphetamine Hydrochloride Tablets are contraindicated in patients with advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, hyperthyroidism, known hypersensitivity or idiosyncrasy to sympathomimetic amines, and glaucoma. (Benzphetamine label, Contraindications)

  • ModafinilCNS stimulantMajor

    Benzphetamine Hydrochloride Tablets should not be used concomitantly with other CNS stimulants. (Benzphetamine label, Contraindications)

  • Benzphetamine Hydrochloride Tablets should not be used concomitantly with other CNS stimulants. (Benzphetamine label, Contraindications)

  • OxymetazolinedecongestantMajor

    CONTRAINDICATIONS Benzphetamine Hydrochloride Tablets are contraindicated in patients with advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, hyperthyroidism, known hypersensitivity or idiosyncrasy to sympathomimetic amines, and glaucoma. (Benzphetamine label, Contraindications)

  • PhendimetrazineCNS stimulantMajor

    Benzphetamine Hydrochloride Tablets should not be used concomitantly with other CNS stimulants. (Benzphetamine label, Contraindications)

  • PhenelzineMAO inhibitorMajor

    Hypertensive crises have resulted when sympathomimetic amines have been used concomitantly or within 14 days following use of monoamine oxidase inhibitors. (Benzphetamine label, Contraindications)

  • PhentermineCNS stimulantMajor

    Benzphetamine Hydrochloride Tablets should not be used concomitantly with other CNS stimulants. (Benzphetamine label, Contraindications)

  • Phentermine and topiramateCNS stimulantMajor

    Benzphetamine Hydrochloride Tablets should not be used concomitantly with other CNS stimulants. (Benzphetamine label, Contraindications)

  • PhenylephrinedecongestantMajor

    CONTRAINDICATIONS Benzphetamine Hydrochloride Tablets are contraindicated in patients with advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, hyperthyroidism, known hypersensitivity or idiosyncrasy to sympathomimetic amines, and glaucoma. (Benzphetamine label, Contraindications)

  • PimozideantipsychoticMajor

    Pimozide should not be used in patients taking drugs that may, themselves, cause motor and phonic tics (e.g., pemoline, methylphenidate and amphetamines) until such patients have been withdrawn from these drugs to determine whether or not the drugs, rather than Tourette’s Disorder, are responsible for the tics. (Pimozide label, Contraindications)

  • PromethazineantihistamineMajor

    Epinephrine Because of the potential for Promethazine to reverse epinephrine's vasopressor effect, epinephrine should NOT be used to treat hypotension associated with Promethazine Syrup overdose. (Promethazine label, Drug interactions)

  • Epinephrine – Because of the potential for promethazine to reverse epinephrine’s vasopressor effect, epinephrine should NOT be used to treat hypotension associated with Promethazine Hydrochloride and Dextromethorphan Hydrobromide Oral Solution overdose. (Promethazine and dextromethorphan label, Drug interactions)

  • Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. (Protamine label, Boxed warning)

  • PseudoephedrinedecongestantMajor

    CONTRAINDICATIONS Benzphetamine Hydrochloride Tablets are contraindicated in patients with advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, hyperthyroidism, known hypersensitivity or idiosyncrasy to sympathomimetic amines, and glaucoma. (Benzphetamine label, Contraindications)

  • RasagilineMAO inhibitorMajor

    Hypertensive crises have resulted when sympathomimetic amines have been used concomitantly or within 14 days following use of monoamine oxidase inhibitors. (Benzphetamine label, Contraindications)

  • Salmeterolbeta-adrenergic agonistMajor

    CONTRAINDICATIONS Benzphetamine Hydrochloride Tablets are contraindicated in patients with advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, hyperthyroidism, known hypersensitivity or idiosyncrasy to sympathomimetic amines, and glaucoma. (Benzphetamine label, Contraindications)

  • SelegilineMAO inhibitorMajor

    Hypertensive crises have resulted when sympathomimetic amines have been used concomitantly or within 14 days following use of monoamine oxidase inhibitors. (Benzphetamine label, Contraindications)

  • Sodium oxybateCNS depressantMajor

    Many patients who received Xyrem during clinical trials in narcolepsy were receiving central nervous system stimulants [see Clinical Trials ( 14 )]. (Sodium oxybate label, Boxed warning)

  • SolriamfetolCNS stimulantMajor

    Benzphetamine Hydrochloride Tablets should not be used concomitantly with other CNS stimulants. (Benzphetamine label, Contraindications)

  • Terbutalinebeta-adrenergic agonistMajor

    CONTRAINDICATIONS Benzphetamine Hydrochloride Tablets are contraindicated in patients with advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, hyperthyroidism, known hypersensitivity or idiosyncrasy to sympathomimetic amines, and glaucoma. (Benzphetamine label, Contraindications)

  • Tizanidinemuscle relaxantMajor

    Hypotension: monitor for signs and symptoms of hypotension, in particular in patients receiving concurrent antihypertensives; Zanaflex should not be used with other α 2 -adrenergic agonists ( 5.1 , 7.7 ) (Tizanidine label, Warnings and precautions)

  • TranylcypromineMAO inhibitorMajor

    Hypertensive crises have resulted when sympathomimetic amines have been used concomitantly or within 14 days following use of monoamine oxidase inhibitors. (Benzphetamine label, Contraindications)

  • Umeclidinium and vilanterolanticholinergicMajor

    CONTRAINDICATIONS Benzphetamine Hydrochloride Tablets are contraindicated in patients with advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, hyperthyroidism, known hypersensitivity or idiosyncrasy to sympathomimetic amines, and glaucoma. (Benzphetamine label, Contraindications)

  • Vibegronbeta-adrenergic agonistMajor

    CONTRAINDICATIONS Benzphetamine Hydrochloride Tablets are contraindicated in patients with advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, hyperthyroidism, known hypersensitivity or idiosyncrasy to sympathomimetic amines, and glaucoma. (Benzphetamine label, Contraindications)

Moderate interactions (157)

  • Acebutololbeta blockerModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Acetazolamidecarbonic anhydrase inhibitorModerate

    Acetazolamide decreases urinary excretion of amphetamine and may enhance the magnitude and duration of their effect. (Acetazolamide label, Drug interactions)

  • AclidiniumanticholinergicModerate

    Sympathomimetics, Methylxanthines, Steroids In clinical studies, concurrent administration of aclidinium bromide and other drugs commonly used in the treatment of COPD including sympathomimetics (short-acting beta 2 agonists), methylxanthines, and oral and inhaled steroids showed no increases in adverse drug reactions. (Aclidinium label, Drug interactions)

  • AliskirenantihypertensiveModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Alogliptin and metforminDPP-4 inhibitorModerate

    Examples: Thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs and isoniazid Alogliptin Cytochrome (CYP) P450, CYP-Substrates or Inhibitors Clinical Impact: Insulin Secretagogues and Insulin Insulin and insulin secretagogues… (Alogliptin and metformin label, Drug interactions)

  • AlprazolambenzodiazepineModerate

    Prescribe the lowest effective dosage; avoid or minimize concomitant use of CNS depressants and other substances associated with abuse, misuse, and addiction (e.g., opioid analgesics, stimulants); and advise patients on the proper disposal of unused drug. (Alprazolam label, Warnings and precautions)

  • Amiloridepotassium-sparing diureticModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • AmiodaroneantiarrhythmicModerate

    • Hypotension: Slow the infusion; as needed, add vasopressor drugs, positive inotropic agents, and volume expansion. (Amiodarone label, Warnings and precautions)

  • Amitriptylinetricyclic antidepressantModerate

    Amphetamines may enhance the effects of tricyclic antidepressants. (Benzphetamine label, Drug interactions)

  • Amlodipinedihydropyridine calcium channel blockerModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Amlodipine and atorvastatindihydropyridine calcium channel blockerModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Amlodipine and benazeprildihydropyridine calcium channel blockerModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Amlodipine and olmesartandihydropyridine calcium channel blockerModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Amlodipine and valsartandihydropyridine calcium channel blockerModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Amoxapinetricyclic antidepressantModerate

    Amphetamines may enhance the effects of tricyclic antidepressants. (Benzphetamine label, Drug interactions)

  • Atenololbeta blockerModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Atenolol and chlorthalidonebeta blockerModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Azilsartanangiotensin II receptor blocker (ARB)Moderate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • BenazeprilACE inhibitorModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Betaxololbeta blockerModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Bisoprololbeta blockerModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • BortezomibModerate

    Management of orthostatic/postural hypotension may include adjustment of antihypertensive medications, hydration, and administration of mineralocorticoids and/or sympathomimetics. (Bortezomib label, Warnings and precautions)

  • Brimonidine and timololalpha-adrenergic agonistModerate

    If necessary during surgery, the effects of beta-adrenergic blocking agents may be reversed by sufficient doses of adrenergic agonists. (Brimonidine and timolol label, Warnings and precautions)

  • BupropionantidepressantModerate

    Amphetamines may enhance the effects of tricyclic antidepressants. (Benzphetamine label, Drug interactions)

  • Candesartanangiotensin II receptor blocker (ARB)Moderate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Candesartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • CaptoprilACE inhibitorModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Carvedilolbeta blockerModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • ChlordiazepoxidebenzodiazepineModerate

    Prescribe the lowest effective dosage; avoid or minimize concomitant use of CNS depressants and other substances associated with abuse, misuse, and addiction (e.g., opioid analgesics, stimulants); and advise patients on the proper disposal of unused drug. (Chlordiazepoxide label, Warnings)

  • Chlordiazepoxide and clidiniumbenzodiazepineModerate

    Prescribe the lowest effective dosage; avoid or minimize concomitant use of CNS depressants and other substances associated with abuse, misuse, and addiction (e.g., opioid analgesics, stimulants); and advise patients on the proper disposal of unused drug. (Chlordiazepoxide and clidinium label, Warnings)

  • Chlorothiazidethiazide diureticModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Chlorthalidonethiazide diureticModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • CitalopramSSRIModerate

    Amphetamines may enhance the effects of tricyclic antidepressants. (Benzphetamine label, Drug interactions)

  • ClobazambenzodiazepineModerate

    Prescribe the lowest effective dosage; avoid or minimize concomitant use of CNS depressants and other substances associated with abuse, misuse, and addiction (e.g., opioid analgesics, stimulants); and advise patients on the proper disposal of unused drug. (Clobazam label, Warnings and precautions)

  • Clomipraminetricyclic antidepressantModerate

    Amphetamines may enhance the effects of tricyclic antidepressants. (Benzphetamine label, Drug interactions)

  • ClonazepambenzodiazepineModerate

    Prescribe the lowest effective dosage; avoid or minimize concomitant use of CNS depressants and other substances associated with abuse, misuse, and addiction (e.g., opioid analgesics, stimulants); and advise patients on the proper disposal of unused drug. (Clonazepam label, Warnings)

  • Clonidinealpha-adrenergic agonistModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • ClorazepatebenzodiazepineModerate

    Prescribe the lowest effective dosage; avoid or minimize concomitant use of CNS depressants and other substances associated with abuse, misuse, and addiction (e.g., opioid analgesics, stimulants); and advise patients on the proper disposal of unused drug. (Clorazepate label, Warnings)

  • Desipraminetricyclic antidepressantModerate

    Amphetamines may enhance the effects of tricyclic antidepressants. (Benzphetamine label, Drug interactions)

  • DesvenlafaxineSNRIModerate

    Amphetamines may enhance the effects of tricyclic antidepressants. (Benzphetamine label, Drug interactions)

  • DiazepambenzodiazepineModerate

    Prescribe the lowest effective dosage; avoid or minimize concomitant use of CNS depressants and other substances associated with abuse, misuse, and addiction (e.g., opioid analgesics, stimulants); and advise patients on the proper disposal of unused drug. (Diazepam label, Warnings)

  • DicyclomineanticholinergicModerate

    …drugs including dicyclomine hydrochloride: amantadine, antiarrhythmic agents of Class I (e.g., quinidine), antihistamines, antipsychotic agents (e.g., phenothiazines), benzodiazepines, MAO inhibitors, narcotic analgesics (e.g., meperidine), nitrates and nitrites, sympathomimetic agents, tricyclic antidepressants, and other drugs having anticholinergic activity. (Dicyclomine label, Drug interactions)

  • Digoxindigitalis glycosideModerate

    Sympathomimetics Epinephrine Can increase the risk of cardiac arrhythmias. (Digoxin label, Drug interactions)

  • Diltiazemcalcium channel blockerModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Dorzolamide and timololcarbonic anhydrase inhibitorModerate

    If necessary during surgery, the effects of beta-adrenergic blocking agents may be reversed by sufficient doses of adrenergic agonists. (Dorzolamide and timolol label, Warnings and precautions)

  • DoxapramModerate

    Drug Interactions Administration of doxapram to patients who are receiving sympathomimetic or monoamine oxidase inhibiting drugs may result in an additive pressor effect (see PRECAUTIONS, General ). (Doxapram label, Drug interactions)

  • Doxazosinalpha blockerModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Doxepintricyclic antidepressantModerate

    Amphetamines may enhance the effects of tricyclic antidepressants. (Benzphetamine label, Drug interactions)

  • DuloxetineSNRIModerate

    Amphetamines may enhance the effects of tricyclic antidepressants. (Benzphetamine label, Drug interactions)

  • EnalaprilACE inhibitorModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • EnalaprilatACE inhibitorModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • EphedrinesympathomimeticModerate

    • Pr e ssor Effect with Concomitant Oxytocic Drugs : Pressor effect of sympathomimetic pressor amines is potentiated (5.1) (Ephedrine label, Warnings and precautions)

  • Eplerenonealdosterone antagonistModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • EscitalopramSSRIModerate

    Amphetamines may enhance the effects of tricyclic antidepressants. (Benzphetamine label, Drug interactions)

  • Esmololbeta blockerModerate

    Sympathomimetic drugs: Dose adjustment needed (7) (Esmolol label, Drug interactions)

  • EstazolambenzodiazepineModerate

    Prescribe the lowest effective dosage; avoid or minimize concomitant use of CNS depressants and other substances associated with abuse, misuse, and addiction (e.g., opioid analgesics, stimulants); and advise patients on the proper disposal of unused drug. (Estazolam label, Warnings)

  • Ethacrynic acidloop diureticModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Felodipinedihydropyridine calcium channel blockerModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • FluoxetineSSRIModerate

    Amphetamines may enhance the effects of tricyclic antidepressants. (Benzphetamine label, Drug interactions)

  • FluvoxamineSSRIModerate

    Amphetamines may enhance the effects of tricyclic antidepressants. (Benzphetamine label, Drug interactions)

  • FosinoprilACE inhibitorModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Furosemideloop diureticModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • GlimepiridesulfonylureaModerate

    …somatropin, protease inhibitors, atypical antipsychotic medications (e.g., olanzapine and clozapine), barbiturates, diazoxide, laxatives, rifampin, thiazides and other diuretics, corticosteroids, phenothiazines, thyroid hormones, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics (e.g., epinephrine, albuterol, terbutaline), and isoniazid. (Glimepiride label, Drug interactions)

  • GlipizidesulfonylureaModerate

    …olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), thyroid hormones, phenytoin, nicotinic acid, and calcium channel blocking drugs. (Glipizide label, Drug interactions)

  • Guanfacinealpha-adrenergic agonistModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • HydralazinevasodilatorModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Hydrochlorothiazidethiazide diureticModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Indapamidethiazide diureticModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Insulin aspartinsulinModerate

    …Insulin Aspart Drugs: Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and thyroid hormones. (Insulin aspart label, Drug interactions)

  • Insulin degludecinsulinModerate

    …Insulin Degludec Drugs: Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and thyroid hormones. (Insulin degludec label, Drug interactions)

  • Insulin detemirinsulinModerate

    …Effect of LEVEMIR Drugs: Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and thyroid hormones. (Insulin detemir label, Drug interactions)

  • Insulin glargineinsulinModerate

    …Glargine-yfgn Drugs: Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and thyroid hormones. (Insulin glargine label, Drug interactions)

  • Insulin lisproinsulinModerate

    …Effect of LYUMJEV Drugs: Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and thyroid hormones. (Insulin lispro label, Drug interactions)

  • Irbesartanangiotensin II receptor blocker (ARB)Moderate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Irbesartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Isradipinedihydropyridine calcium channel blockerModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • KetamineCNS depressantModerate

    Sympathomimetics and Vasopressin : Sympathomimetics and vasopressin may enhance the sympathomimetic effects of ketamine [see Drug Interactions ( 7.2 )] . (Ketamine label, Warnings and precautions)

  • Labetalolbeta blockerModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • LevomilnacipranSNRIModerate

    Amphetamines may enhance the effects of tricyclic antidepressants. (Benzphetamine label, Drug interactions)

  • Levothyroxinethyroid hormoneModerate

    Sympathomimetics Concurrent use may of sympathomimetics and levothyroxine may increase the effects of sympathomimetics or thyroid hormone. (Levothyroxine label, Drug interactions)

  • Lidocainelocal anestheticModerate

    Concurrent administration of vasopressor drugs (for the treatment of hypotension related to obstetric blocks) and ergot-type oxytocic drugs may cause severe, persistent hypertension or cerebrovascular accidents. (Lidocaine label, Drug interactions)

  • LisinoprilACE inhibitorModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Lofexidinealpha-adrenergic agonistModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • LorazepambenzodiazepineModerate

    Prescribe the lowest effective dosage; avoid or minimize concomitant use of CNS depressants and other substances associated with abuse, misuse, and addiction (e.g., opioid analgesics, stimulants); and advise patients on the proper disposal of unused drug. (Lorazepam label, Warnings and precautions)

  • Losartanangiotensin II receptor blocker (ARB)Moderate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Losartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • MecamylamineantihypertensiveModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • MethyldopaantihypertensiveModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Metolazonethiazide diureticModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Metoprololbeta blockerModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • MilnacipranSNRIModerate

    The risk is increased with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, tramadol, meperidine, methadone, lithium, tryptophan, buspirone, amphetamines, and St. (Milnacipran label, Warnings and precautions)

  • MinoxidilvasodilatorModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • MirtazapineantidepressantModerate

    Amphetamines may enhance the effects of tricyclic antidepressants. (Benzphetamine label, Drug interactions)

  • MoexiprilACE inhibitorModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Nadololbeta blockerModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Naltrexone and bupropionopioid antagonistModerate

    Amphetamines may enhance the effects of tricyclic antidepressants. (Benzphetamine label, Drug interactions)

  • NateglinidemeglitinideModerate

    Drugs and Herbals That May Reduce the Blood-Glucose-Lowering Effect of Nateglinide and Increase Susceptibility to Hyperglycemia Drugs: Thiazides, corticosteroids, thyroid products, sympathomimetics, somatropin, somatostatin analogues (e.g., lanreotide, octreotide), and CYP inducers (e.g., rifampin, phenytoin and St John's Wort). (Nateglinide label, Drug interactions)

  • Nebivololbeta blockerModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • NefazodoneantidepressantModerate

    Amphetamines may enhance the effects of tricyclic antidepressants. (Benzphetamine label, Drug interactions)

  • Nicardipinedihydropyridine calcium channel blockerModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Nifedipinedihydropyridine calcium channel blockerModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Nisoldipinedihydropyridine calcium channel blockerModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • NitroprussidevasodilatorModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Nortriptylinetricyclic antidepressantModerate

    Amphetamines may enhance the effects of tricyclic antidepressants. (Benzphetamine label, Drug interactions)

  • Olanzapine and fluoxetineantipsychoticModerate

    Amphetamines may enhance the effects of tricyclic antidepressants. (Benzphetamine label, Drug interactions)

  • Olmesartanangiotensin II receptor blocker (ARB)Moderate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Olmesartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Olmesartan, amlodipine, and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • OxazepambenzodiazepineModerate

    Prescribe the lowest effective dosage; avoid or minimize concomitant use of CNS depressants and other substances associated with abuse, misuse, and addiction (e.g., opioid analgesics, stimulants); and advise patients on the proper disposal of unused drug. (Oxazepam label, Warnings)

  • ParoxetineSSRIModerate

    Amphetamines may enhance the effects of tricyclic antidepressants. (Benzphetamine label, Drug interactions)

  • PerindoprilACE inhibitorModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Phenoxybenzaminealpha blockerModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Pindololbeta blockerModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Pioglitazone and glimepiridethiazolidinedioneModerate

    …somatropin, protease inhibitors, atypical antipsychotic medications (e.g., olanzapine and clozapine), barbiturates, diazoxide, laxatives, rifampin, thiazides and other diuretics, corticosteroids, phenothiazines, thyroid hormones, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics (e.g., epinephrine, albuterol, terbutaline), and isoniazid. (Pioglitazone and glimepiride label, Drug interactions)

  • Prazosinalpha blockerModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Propranololbeta blockerModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Protriptylinetricyclic antidepressantModerate

    Amphetamines may enhance the effects of tricyclic antidepressants. (Benzphetamine label, Drug interactions)

  • QuinaprilACE inhibitorModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • RamiprilACE inhibitorModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • RitonavirantiretroviralModerate

    Anesthetic: meperidine ↓ meperidine/ ↑ normeperidine (metabolite) Dosage increase and long-term use of meperidine with ritonavir are not recommended due to the increased concentrations of the metabolite normeperidine which has both analgesic activity and CNS stimulant activity (e.g., seizures). (Ritonavir label, Drug interactions)

  • Sacubitril and valsartanangiotensin II receptor blocker (ARB)Moderate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • SertralineSSRIModerate

    Amphetamines may enhance the effects of tricyclic antidepressants. (Benzphetamine label, Drug interactions)

  • Sotalolbeta blockerModerate

    Beta-2-Receptor Stimulants Beta-agonists such as albuterol, terbutaline and isoproterenol may have to be administered in increased dosages when used concomitantly with sotalol. (Sotalol label, Drug interactions)

  • Spironolactonealdosterone antagonistModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Spironolactone and hydrochlorothiazidealdosterone antagonistModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • SugammadexModerate

    The most commonly described clinical features in reports of anaphylaxis were dermatologic symptoms (including urticaria, rash, erythema, flushing and skin eruption); and clinically important hypotension often requiring the use of vasopressors for circulatory support. (Sugammadex label, Warnings and precautions)

  • Circulatory Shock Circulatory shock with fever, severe hypotension, and confusion requiring intravenous fluid resuscitation and vasopressors has occurred within minutes to hours of re-challenge with trimethoprim-sulfamethoxazole products in patients with history of recent (days to weeks) exposure to sulfamethoxazole and trimethoprim. (Sulfamethoxazole and trimethoprim label, Warnings)

  • Telmisartanangiotensin II receptor blocker (ARB)Moderate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Telmisartan and amlodipineangiotensin II receptor blocker (ARB)Moderate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Telmisartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • TemazepambenzodiazepineModerate

    Prescribe the lowest effective dosage; avoid or minimize concomitant use of CNS depressants and other substances associated with abuse, misuse, and addiction (e.g., opioid analgesics, stimulants); and advise patients on the proper disposal of unused drug. (Temazepam label, Warnings)

  • Terazosinalpha blockerModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Timololbeta blockerModerate

    If necessary during surgery, the effects of beta-adrenergic blocking agents may be reversed by sufficient doses of adrenergic agonists. (Timolol label, Warnings and precautions)

  • TiotropiumanticholinergicModerate

    Concomitant Respiratory Medications SPIRIVA RESPIMAT has been used concomitantly with short-acting and long-acting sympathomimetic (beta-agonists) bronchodilators, methylxanthines, oral and inhaled steroids, antihistamines, mucolytics, leukotriene modifiers, cromones, and anti-IgE treatment without increases in adverse reactions. (Tiotropium label, Drug interactions)

  • TolcaponeModerate

    Drugs That Increase Catecholamines: Tolcapone did not influence the effect of ephedrine, an indirect sympathomimetic, on hemodynamic parameters or plasma catecholamine levels, either at rest or during exercise. (Tolcapone label, Drug interactions)

  • Torsemideloop diureticModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • TrandolaprilACE inhibitorModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • TrazodoneantidepressantModerate

    Amphetamines may enhance the effects of tricyclic antidepressants. (Benzphetamine label, Drug interactions)

  • Triamterenepotassium-sparing diureticModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Triamterene and hydrochlorothiazidepotassium-sparing diureticModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • TriazolambenzodiazepineModerate

    Prescribe the lowest effective dosage; avoid or minimize concomitant use of CNS depressants and other substances associated with abuse, misuse, and addiction (e.g., opioid analgesics, stimulants); and advise patients on the proper disposal of unused drug. (Triazolam label, Warnings and precautions)

  • Trimipraminetricyclic antidepressantModerate

    Amphetamines may enhance the effects of tricyclic antidepressants. (Benzphetamine label, Drug interactions)

  • Valsartanangiotensin II receptor blocker (ARB)Moderate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • Valsartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • VenlafaxineSNRIModerate

    Amphetamines may enhance the effects of tricyclic antidepressants. (Benzphetamine label, Drug interactions)

  • Verapamilcalcium channel blockerModerate

    Amphetamines may decrease the hypotensive effect of antihypertensives. (Benzphetamine label, Drug interactions)

  • VilazodoneSSRIModerate

    Amphetamines may enhance the effects of tricyclic antidepressants. (Benzphetamine label, Drug interactions)

  • VortioxetineantidepressantModerate

    Amphetamines may enhance the effects of tricyclic antidepressants. (Benzphetamine label, Drug interactions)

  • ZiprasidoneantipsychoticModerate

    The risk is increased with concomitant use of other serotonergic drugs (including selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), triptans, tricyclic antidepressants, fentanyl, tramadol, meperidine, methadone, lithium, tryptophan, buspirone, amphetamines, and St. (Ziprasidone label, Warnings and precautions)

Minor mentions (21)

  • AcarboseantidiabeticMinor

    These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel-blocking drugs, and isoniazid. (Acarbose label, Drug interactions)

  • AmantadineanticholinergicMinor

    Drug Interactions Careful observation is required when amantadine hydrochloride is administered concurrently with central nervous system stimulants. (Amantadine label, Drug interactions)

  • Severe reactions have required intervention with vasopressor agents and supportive measures. (Benzonatate label, Warnings)

  • Bromocriptinedopamine agonistMinor

    There are postmarketing reports of hypertension and tachycardia when bromocriptine was co-administered with sympathomimetic drugs (e.g., phenylpropanolamine and isometheptene) in postpartum women. (Bromocriptine label, Drug interactions)

  • Dapagliflozin and metforminSGLT2 inhibitorMinor

    These medications include thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid. (Dapagliflozin and metformin label, Drug interactions)

  • Empagliflozin and metforminSGLT2 inhibitorMinor

    These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid. (Empagliflozin and metformin label, Drug interactions)

  • Glipizide and metforminsulfonylureaMinor

    These drugs include thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid. (Glipizide and metformin label, Precautions)

  • GlyburidesulfonylureaMinor

    These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid. (Glyburide label, Drug interactions)

  • Glyburide and metforminsulfonylureaMinor

    Examples: Thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blockers, and isoniazid. (Glyburide and metformin label, Drug interactions)

  • Atypical Antipsychotics (e.g., olanzapine and clozapine), Corticosteroids, Danazol, Diuretics, Estrogens, Glucagon, Isoniazid, Niacin, Oral Contraceptives, Phenothiazines, Progestogens (e.g., in oral contraceptives), Protease inhibitors, Somatropin, Sympathomimetic Agents (e.g., albuterol, epinephrine, terbutaline) and Thyroid Hormones. (Insulin regular (human) label, Drug interactions)

  • IpratropiumanticholinergicMinor

    ATROVENT HFA has been used concomitantly with other drugs, including sympathomimetic bronchodilators, methylxanthines, oral and inhaled steroids commonly used in the treatment of COPD. (Ipratropium label, Drug interactions)

  • Linagliptin and metforminDPP-4 inhibitorMinor

    These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid. (Linagliptin and metformin label, Drug interactions)

  • MetforminbiguanideMinor

    Examples: Thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blockers, and isoniazid. (Metformin label, Drug interactions)

  • PerphenazineantipsychoticMinor

    If a vasopressor is needed, norepinephrine may be used. (Perphenazine label, Warnings)

  • Pioglitazone and metforminthiazolidinedioneMinor

    These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blockers, and isoniazid. (Pioglitazone and metformin label, Drug interactions)

  • PropofolCNS depressantMinor

    These effects are responsive to discontinuation of DIPRIVAN, intravenous fluid administration, and/or vasopressor therapy. (Propofol label, Warnings and precautions)

  • Ramelteonsedative-hypnoticMinor

    In addition, in vitro data indicate that ramelteon does not cause false-positive results for benzodiazepines, opiates, barbiturates, cocaine, cannabinoids, or amphetamines in two standard urine drug screening methods in vitro . (Ramelteon label, Warnings and precautions)

  • RepaglinidemeglitinideMinor

    …antipsychotics (e.g., olanzapine and clozapine), calcium channel antagonists, corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and thyroid hormones. (Repaglinide label, Drug interactions)

  • Saxagliptin and metforminDPP-4 inhibitorMinor

    These medications include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid. (Saxagliptin and metformin label, Drug interactions)

  • Sitagliptin and metforminDPP-4 inhibitorMinor

    Examples: Thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blockers, and isoniazid. (Sitagliptin and metformin label, Drug interactions)

  • TiagabineanticonvulsantMinor

    In most cases, patients were using concomitant medications (antidepressants, antipsychotics, stimulants, narcotics) that are thought to lower the seizure threshold. (Tiagabine label, Warnings)

Check Benzphetamine against everything you take. Add your full list; every pair is checked at once.

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.