Antacids (Tums, Maalox, Mylanta) and Diflunisal interaction
Antacids (Tums, Maalox, Mylanta) and Diflunisal: the Diflunisal prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Diflunisal label · effective 2026-08-04
Antacids Concomitant administration of antacids may reduce plasma levels of diflunisal.
This effect is small with occasional doses of antacids, but may be clinically significant when antacids are used on a continuous schedule.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.