Apixaban and Protamine interaction
Apixaban and Protamine: the Apixaban prescribing label reports no clinically significant interaction between these two.
No interaction
No clinically significant interaction reported. The label studied or considered this pair and found nothing meaningful.
What the FDA labels say
From the Apixaban (ELIQUIS) label · effective 2026-04-24
No interaction
Protamine sulfate and vitamin K are not expected to affect the anticoagulant activity of apixaban.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.