Benzphetamine and Modafinil interaction

Benzphetamine and Modafinil: the Benzphetamine prescribing label flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.

Major

Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.

What the FDA labels say

From the Benzphetamine (Benzphetamine Hydrochloride) label · effective 2026-06-18

Major

Benzphetamine Hydrochloride Tablets should not be used concomitantly with other CNS stimulants.

Contraindicationsby drug classView label on DailyMed
Major

Benzphetamine hydrochloride tablets should not be used concomitantly with other CNS stimulants.

Drug interactionsby drug classView label on DailyMed

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Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.