Bisoprolol and hydrochlorothiazide and Levalbuterol interaction
Bisoprolol and hydrochlorothiazide and Levalbuterol: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Levalbuterol (XOPENEX HFA) label · effective 2025-06-02
In this setting, cardioselective beta-blockers should be considered, although they should be administered with caution.
Diuretics The ECG changes or hypokalemia that may result from the administration of non-potassium-sparing diuretics (such as loop and thiazide diuretics) can be acutely worsened by beta-agonists, especially when the recommended dose of the beta-agonist is exceeded.
Although the clinical significance of these effects is not known, caution is advised in the coadministration of beta-agonists with non-potassium-sparing diuretics.
Beta-blockers : May block bronchodilatory effects of beta-agonists and produce severe bronchospasm.
Patients with asthma should not normally be treated with beta-blockers.
From the Bisoprolol and hydrochlorothiazide (bisoprolol fumarate and hydrochlorothiazide) label · effective 2026-08-11
A beta 2 agonist (bronchodilator) should be made available.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.