Brimonidine and Duloxetine interaction
Brimonidine and Duloxetine: the Brimonidine prescribing label describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Brimonidine (Brimonidine tartrate) label · effective 2025-09-18
Caution is advised in patients taking tricyclic antidepressants which can affect the metabolism and uptake of circulating amines.
Tricyclic antidepressants may potentially blunt the hypotensive effect of systemic clonidine.
Tricyclic Antidepressants Tricyclic antidepressants have been reported to blunt the hypotensive effect of systemic clonidine.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.