Brimonidine and timolol and Oxymetazoline interaction
Brimonidine and timolol and Oxymetazoline: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Brimonidine and timolol (Brimonidine Tartrate/Timolol Maleate Ophthalmic Solution) label · effective 2025-05-30
If necessary during surgery, the effects of beta-adrenergic blocking agents may be reversed by sufficient doses of adrenergic agonists.
From the Oxymetazoline (UPNEEQ) label · effective 2026-07-23
Caution in using drugs such as beta-blockers, anti-hypertensives, and/or cardiac glycosides is advised.
Alpha-adrenergic agonists as a class may impact blood pressure.
Potential Impacts on Cardiovascular Disease Alpha-adrenergic agonists may impact blood pressure.
Anti-hypertensives/Cardiac Glycosides Alpha-adrenergic agonists, as a class, may impact blood pressure.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.