Buprenorphine and Rasagiline interaction
Buprenorphine and Rasagiline: the Buprenorphine prescribing label flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Buprenorphine (BELBUCA) label · effective 2026-01-02
Monoamine Oxidase Inhibitors (MAOIs) Clinical Impact: MAOI interactions with opioids may manifest as serotonin syndrome opioid toxicity (e.g., respiratory depression, coma) [see Warnings and Precautions (5.2) ].
Intervention: The use of BELBUCA is not recommended for patients taking MAOIs or within 14 days of stopping such treatment.
Serotonergic Drugs : Concomitant use may result in serotonin syndrome.
Avoid concomitant use in patients receiving MAOIs or within 14 days of stopping treatment with an MAOI.
Monoamine Oxidase Inhibitors (MAOIs) : Can potentiate the effects of buprenorphine.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.