Bupropion and Carbidopa, levodopa, and entacapone interaction

Bupropion and Carbidopa, levodopa, and entacapone: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.

Moderate

Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.

What the FDA labels say

From the Bupropion (BUPROPION HCl ER (XL)) label · effective 2026-02-04

Moderate

CNS toxicity has been reported when bupropion was coadministered with levodopa or amantadine.

Drug interactionsnames Carbidopa, levodopa, and entacaponeView label on DailyMed

Moderate

Because there is no lower strength for bupropion hydrochloride extended-release tablets (XL), administration of bupropion hydrochloride extended-release tablets (XL) to patients receiving either levodopa or amantadine concurrently should be undertaken with caution.

Drug interactionsnames Carbidopa, levodopa, and entacaponeView label on DailyMed

Moderate

The risk of hypertension is increased if bupropion hydrochloride extended-release tablets (XL) are used concomitantly with MAOIs or other drugs that increase dopaminergic or noradrenergic activity [see Contraindications (4)] .

Warnings and precautionsby drug classView label on DailyMed

Moderate

Dopaminergic Drugs (levodopa and amantadine): CNS toxicity can occur when used concomitantly with bupropion hydrochloride extended-release tablets (XL) (7.4).

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Minor

Dopaminergic Drugs (Levodopa and Amantadine) Bupropion, levodopa, and amantadine have dopamine agonist effects.

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From the Carbidopa, levodopa, and entacapone (Carbidopa, Levodopa and Entacapone) label · effective 2026-04-08

Moderate

• Tricyclic antidepressants: risk of hypertension and dyskinesia reported during concomitant use with carbidopa/levodopa ( 7.4 )

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Minor

Tricyclic Antidepressants There have been reports of adverse reactions, including hypertension and dyskinesia, resulting from the concomitant use of tricyclic antidepressants and carbidopa/levodopa.

Drug interactionsby drug classView label on DailyMed

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Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.