Calcium chloride and Digoxin interaction
Calcium chloride and Digoxin: the Calcium chloride prescribing label flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Calcium chloride label · effective 2026-02-02
• Arrhythmias with Concomitant Digoxin Use: Avoid use of Calcium Chloride Injection in patients receiving digoxin.
Avoid the use of Calcium Chloride Injection in patients receiving digoxin.
• Digoxin: Avoid concomitant use with Calcium Chloride Injection.
Digoxin Avoid the concomitant use of Calcium Chloride Injection with digoxin.
Hypercalcemia resulting from an overdose of Calcium Chloride Injection increases the risk of digoxin toxicity.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.