Carvedilol and Flecainide interaction
Carvedilol and Flecainide: the Flecainide prescribing label flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Flecainide (Flecainide Acetate) label · effective 2026-02-06
Concomitant negative chronotropic therapy such as digoxin or beta-blockers may lower the risk of this complication.
In flecainide acetate clinical trials, patients who were receiving beta blockers concurrently did not experience an increased incidence of side effects.
Nevertheless, the possibility of additive negative inotropic effects of beta blockers and flecainide should be recognized.
Drug Interactions Flecainide acetate has been administered to patients receiving digitalis preparations or beta-adrenergic blocking agents without adverse effects.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.