CBD (cannabidiol) and Divalproex (valproate) interaction
CBD (cannabidiol) and Divalproex (valproate): the Divalproex (valproate) prescribing label describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Divalproex (valproate) (Depakote ER) label · effective 2026-03-31
Cannabidiol Concomitant administration of valproate and cannabidiol has been associated with an increased risk of ALT and/or AST elevation.
Cannabidiol: ALT and/or AST elevation ( 7.4 )
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.