CBD (cannabidiol) interactions
CBD inhibits several CYP enzymes and has documented interactions with some seizure medicines and blood thinners.
CBD (cannabidiol) has 6 documented interactions across the FDA labels and fact sheets we index: 0 major, 6 moderate, 0 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This tobacco and cannabis page is a starting point, not a verdict for your situation.
Moderate interactions (6)
- Cannabidiol (prescription)anticonvulsantModerate
Effect of Other Drugs on EPIDIOLEX Strong CYP3A4 or CYP2C19 Inducers Concomitant use with a strong CYP3A4 and CYP2C19 inducer (rifampin 600 mg once daily) decreased cannabidiol and 7-hydroxy-cannabidiol (7-OH-CBD) plasma concentrations by approximately 32% and 63%. (Cannabidiol (prescription) label, Drug interactions)
- ClobazambenzodiazepineModerate
Cannabidiol: May increase risk of SYMPAZAN-related adverse reactions; consider dosage adjustment if this occurs ( 7.4 ) (Clobazam label, Drug interactions)
Cannabidiol Concomitant administration of valproate and cannabidiol has been associated with an increased risk of ALT and/or AST elevation. (Divalproex (valproate) label, Drug interactions)
- EverolimusimmunosuppressantModerate
Cannabidiol Drug Interactions When cannabidiol and Zortress are coadministered, closely monitor for an increase in everolimus blood levels and for adverse reactions suggestive of everolimus toxicity. (Everolimus label, Warnings and precautions)
- SirolimusimmunosuppressantModerate
Cannabidiol Drug Interactions When cannabidiol and sirolimus are co-administered, closely monitor for an increase in sirolimus blood levels and for adverse reactions suggestive of sirolimus toxicity. (Sirolimus label, Warnings and precautions)
Cannabidiol Drug Interactions When cannabidiol and ASTAGRAF XL are co-administered, closely monitor for an increase in tacrolimus blood levels and for adverse reactions suggestive of tacrolimus toxicity. (Tacrolimus label, Warnings and precautions)
Check CBD (cannabidiol) against everything you take. Add your full list; every pair is checked at once.
Open in the checkerNot medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.