CBD (cannabidiol) and Everolimus interaction
CBD (cannabidiol) and Everolimus: the Everolimus prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Everolimus (Zortress) label · effective 2026-02-12
Cannabidiol Drug Interactions When cannabidiol and Zortress are coadministered, closely monitor for an increase in everolimus blood levels and for adverse reactions suggestive of everolimus toxicity.
A dose reduction of Zortress should be considered as needed when Zortress is coadministered with cannabidiol [see Dosage and Administration (2.3), Drug Interactions (7.13)] .
Therapeutic drug monitoring and dose reduction for Zortress should be considered when Zortress is coadministered with cannabidiol ( 5.22 , 7.13 )
Cannabidiol The blood levels of everolimus may increase upon concomitant use with cannabidiol.
When cannabidiol and Zortress are coadministered, closely monitor for an increase in everolimus blood levels and for adverse reactions suggestive of everolimus toxicity.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.