Cholestyramine and Naproxen interaction
Cholestyramine and Naproxen: the Naproxen prescribing label flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Naproxen label · effective 2026-01-05
Intervention: Concomitant administration of cholestyramine with Naproxen Suspension is not recommended.
Cholestyramine Clinical Impact: Concomitant administration of cholestyramine can delay the absorption of naproxen.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.