Cholestyramine and Raloxifene interaction
Cholestyramine and Raloxifene: the Raloxifene prescribing label flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Raloxifene (Evista) label · effective 2026-02-11
Cholestyramine : Use with EVISTA is not recommended.
Cholestyramine Concomitant administration of cholestyramine with EVISTA is not recommended.
EVISTA should not be co-administered with other anion exchange resins [see Clinical Pharmacology ( 12.3 )] .
Although not specifically studied, it is anticipated that other anion exchange resins would have a similar effect.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.