Clobazam and Trazodone interaction
Clobazam and Trazodone: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Clobazam (SYMPAZAN) label · effective 2025-12-01
Risk may be increased with concomitant use of other CNS depressants ( 5.4 , 5.5 )
Prescribers should monitor patients for somnolence and sedation, particularly with concomitant use of other central nervous system depressants.
Therefore, caution patients or their caregivers against simultaneous use with other CNS depressant drugs or alcohol, and caution that the effects of other CNS depressant drugs or alcohol may be potentiated [see Warnings and Precautions (5.4) ].
From the Trazodone (RALDESY TM) label · effective 2026-09-01
CNS Depressants: RALDESY may enhance effects of alcohol, barbiturates, or other CNS depressants ( 7 ).
CYP3A4 Inducers: Increase in RALDESY dosage may be necessary ( 2.5 , 7 ).
Strong CYP3A4 Inducers Clinical Impact: The concomitant use of RALDESY and strong CYP3A4 inducers decreased the exposure of trazodone compared to the use of RALDESY alone.
Intervention: Patients should be closely monitored to see if there is a need for an increased dose of RALDESY when taking CYP3A4 inducers [see Dosage and Administration (2.5) ].
Central Nervous System (CNS) Depressants Clinical Impact: RALDESY may enhance the response CNS depressants.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.