Cyclophosphamide and Rituximab interaction

Cyclophosphamide and Rituximab: the Rituximab prescribing label reports no clinically significant interaction between these two.

No interaction

No clinically significant interaction reported. The label studied or considered this pair and found nothing meaningful.

What the FDA labels say

From the Rituximab (Riabni) label · effective 2026-07-22

No interaction

In patients with CLL, rituximab did not alter systemic exposure to fludarabine or cyclophosphamide.

Drug interactionsnames CyclophosphamideView label on DailyMed
No interaction

In clinical trials of patients with RA, concomitant administration of methotrexate or cyclophosphamide did not alter the pharmacokinetics of rituximab.

Drug interactionsnames CyclophosphamideView label on DailyMed

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Open in the checker

Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.