Dapsone and Pyrimethamine interaction
Dapsone and Pyrimethamine: the Dapsone prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Dapsone label · effective 2026-07-20
Folic acid antagonists such as pyrimethamine may increase the likelihood of hematologic reactions.
Patients on weekly pyrimethamine and dapsone have developed agranulocytosis during the second and third month of therapy.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.