Folic acid (folate) and Pyrimethamine interaction
Folic acid (folate) and Pyrimethamine: the Pyrimethamine prescribing label flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Pyrimethamine (Daraprim) label · effective 2023-12-07
Use of the drug is also contraindicated in patients with documented megaloblastic anemia due to folate deficiency.
If signs of folate deficiency develop (see ADVERSE REACTIONS ), reduce the dosage or discontinue the drug according to the response of the patient.
If signs of folate deficiency develop, pyrimethamine should be discontinued.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.