Daptomycin and Dexamethasone interaction

Daptomycin and Dexamethasone: the Daptomycin prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.

Moderate

Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.

What the FDA labels say

From the Daptomycin label · effective 2026-03-23

Moderate

Eosinophilic pneumonia: Discontinue Daptomycin for Injection and consider treatment with systemic steroids.

Warnings and precautionsby drug classView label on DailyMed
Minor

In general, patients developed eosinophilic pneumonia 2 to 4 weeks after starting daptomycin for injection and improved when daptomycin for injection was discontinued and steroid therapy was initiated.

Warnings and precautionsby drug classView label on DailyMed
Minor

Treatment with systemic steroids is recommended.

Warnings and precautionsby drug classView label on DailyMed

Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.

Open in the checker

Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.