Darunavir and cobicistat and Dorzolamide and timolol interaction
Darunavir and cobicistat and Dorzolamide and timolol: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Dorzolamide and timolol (COSOPT PF) label · effective 2026-05-13
CYP2D6 inhibitors may potentiate systemic beta-blockade.
CYP2D6 Inhibitors Potentiated systemic beta-blockade (e.g., decreased heart rate, depression) has been reported during combined treatment with CYP2D6 inhibitors (e.g., quinidine, SSRIs) and timolol.
From the Darunavir and cobicistat (PREZCOBIX) label · effective 2026-02-01
Monitor in patients with a known sulfonamide allergy.
Monitor patients with a known sulfonamide allergy after initiating PREZCOBIX or PREZCOBIX PED.
Initiation of quetiapine in patients taking PREZCOBIX or PREZCOBIX PED : Refer to the quetiapine prescribing information for initial dosing and titration of quetiapine. β-Blockers: e.g. carvedilol, metoprolol, timolol ↑ beta-blockers Clinical monitoring is recommended for co-administration with beta-blockers that are metabolized by CYP2D6.
Sulfa Allergy Darunavir contains a sulfonamide moiety.
In clinical studies with darunavir co-administered with ritonavir, the incidence and severity of rash were similar in participants with or without a history of sulfonamide allergy.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.