التداخل بين دارونافير وكوبيسيستات ودورزولاميد وتيمولول

CYP2D6 inhibitors may potentiate systemic beta-blockade.

CYP2D6 Inhibitors Potentiated systemic beta-blockade (e.g., decreased heart rate, depression) has been reported during combined treatment with CYP2D6 inhibitors (e.g., quinidine, SSRIs) and timolol.

Monitor in patients with a known sulfonamide allergy.

Monitor patients with a known sulfonamide allergy after initiating PREZCOBIX or PREZCOBIX PED.

Initiation of quetiapine in patients taking PREZCOBIX or PREZCOBIX PED : Refer to the quetiapine prescribing information for initial dosing and titration of quetiapine. β-Blockers: e.g. carvedilol, metoprolol, timolol ↑ beta-blockers Clinical monitoring is recommended for co-administration with beta-blockers that are metabolized by CYP2D6.

Sulfa Allergy Darunavir contains a sulfonamide moiety.

In clinical studies with darunavir co-administered with ritonavir, the incidence and severity of rash were similar in participants with or without a history of sulfonamide allergy.