Desogestrel and ethinyl estradiol and Tobacco and smoking interaction
Desogestrel and ethinyl estradiol and Tobacco and smoking: the Desogestrel and ethinyl estradiol prescribing label flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Desogestrel and ethinyl estradiol label · effective 2026-06-24
WARNING: CARDIOVASCULAR RISK ASSOCIATED WITH SMOKING Cigarette smoking increases the risk of serious cardiovascular events from combination oral contraceptive use.
This risk increases with age, particularly in women over 35 years of age, and with the number of cigarettes smoked.
WARNINGS Cigarette smoking increases the risk of serious cardiovascular events from combination oral contraceptive use.
This risk is primarily in smokers or women with other underlying risk factors for coronary artery disease such as hypertension, hypercholesterolemia, morbid obesity, and diabetes.
Mortality rates associated with circulatory disease have been shown to increase substantially in smokers, especially in those 35 years of age and older and in nonsmokers over the age of 40 among women who use oral contraceptives (see Figure 1).
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