Drospirenone and ethinyl estradiol and Tobacco and smoking interaction
Drospirenone and ethinyl estradiol and Tobacco and smoking: the Drospirenone and ethinyl estradiol prescribing label flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Drospirenone and ethinyl estradiol (Yaz) label · effective 2025-05-29
WARNING: CIGARETTE SMOKING AND SERIOUS CARDIOVASCULAR EVENTS Cigarette smoking increases the risk of serious cardiovascular events from combination oral contraceptives (COC) use.
This risk increases with age, particularly in women over 35 years of age, and with the number of cigarettes smoked.
WARNING: CIGARETTE SMOKING AND SERIOUS CARDIOVASCULAR EVENTS See full prescribing information for complete boxed warning.
• Cigarette smoking increases the risk of serious cardiovascular events from combination oral contraceptive (COC) use.
Known risk factors for VTE include smoking, obesity, and family history of VTE, in addition to other factors that contraindicate use of COCs [see Contraindications ( 4 )] .
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