Dextromethorphan and quinidine and Rasagiline interaction
Dextromethorphan and quinidine and Rasagiline: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Rasagiline label · effective 2020-06-30
Rasagiline is contraindicated for use with dextromethorphan because of risk of episode of psychosis or bizarre behavior.
Concomitant use of meperidine, tramadol, methadone, propoxyphene dextromethorphan, St.
Therefore, in view of rasagiline’s MAO inhibitory activity, dextromethorphan is contraindicated for use with rasagiline [see Contraindications ( 4 )] .
Dextromethorphan: Risk of psychosis or bizarre behavior ( 4 , 7.2 )
Dextromethorphan The concomitant use of rasagiline and dextromethorphan was not allowed in clinical studies.
From the Dextromethorphan and quinidine (Nuedexta) label · effective 2026-01-22
Use with an MAOI or within 14 days of stopping an MAOI.
Allow 14 days after stopping NUEDEXTA before starting an MAOI.
MAOIs NUEDEXTA is contraindicated in patients taking monoamine oxidase inhibitors (MAOIs) or in patients who have taken MAOIs within the preceding 14 days, due to the risk of serious and possibly fatal drug interactions, including serotonin syndrome.
Allow at least 14 days after stopping NUEDEXTA before starting an MAOI [ see Drug Interactions ( 7.1 ) ] .
MAOIs Do not use NUEDEXTA with monoamine oxidase inhibitors (MAOIs) or in patients who have taken MAOIs within the preceding 14 days [ see Contraindications ( 4.3 ) ] .
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.