Dextromethorphan and Rasagiline interaction
Dextromethorphan and Rasagiline: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Dextromethorphan (Delsym) label · effective 2026-05-27
Warnings Do not use if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug.
If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.
From the Rasagiline label · effective 2020-06-30
Rasagiline is contraindicated for use with dextromethorphan because of risk of episode of psychosis or bizarre behavior.
Concomitant use of meperidine, tramadol, methadone, propoxyphene dextromethorphan, St.
Therefore, in view of rasagiline’s MAO inhibitory activity, dextromethorphan is contraindicated for use with rasagiline [see Contraindications ( 4 )] .
Dextromethorphan: Risk of psychosis or bizarre behavior ( 4 , 7.2 )
Dextromethorphan The concomitant use of rasagiline and dextromethorphan was not allowed in clinical studies.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.