Diazepam and Theophylline interaction
Diazepam and Theophylline: the Theophylline prescribing label flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Theophylline label · effective 2026-01-29
Discontinuation of theophylline without reduction of diazepam dose may result in respiratory depression.
Larger diazepam doses may be required to produce desired level of sedation.
30% increase Flurazepam Similar to diazepam.
80% increase Midazolam Similar to diazepam.
25% increase Diazepam Benzodiazepines increase CNS concentrations of adenosine, a potent CNS depressant, while theophylline blocks adenosine receptors.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.