Diclofenac and misoprostol and Magnesium interaction
Diclofenac and misoprostol and Magnesium: the Diclofenac and misoprostol prescribing label flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Diclofenac and misoprostol (Diclofenac sodium and Misoprostol) label · effective 2026-08-31
Intervention: Concomitant use of diclofenac sodium/misoprostol and magnesium-containing antacids is not recommended.
Magnesium-containing antacids exacerbate misoprostol-associated diarrhea.
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.