Digoxin and Ephedrine interaction
Digoxin and Ephedrine: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Digoxin label · effective 2025-04-10
Sympathomimetics Epinephrine Can increase the risk of cardiac arrhythmias.
From the Ephedrine (Ephedrine Sulfate) label · effective 2026-03-17
Cardiac glycosides C linical Impact: Giving ephedrine with a cardiac glycoside, such as digitalis, may increase the possibility of arrhythmias.
I ntervention: Carefully monitor patients on cardiac glycosides who are also administered ephedrine.
• Ca rd i a c glycosides : Giving ephedrine with a cardiac glycoside, such as digitalis, may increase the possibility of arrhythmias.
Carefully monitor patients on cardiac glycosides who are also administered ephedrine.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.