Digoxin and Levothyroxine interaction
Digoxin and Levothyroxine: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Digoxin label · effective 2025-04-10
Use in Thyroid Disorders and Hypermetabolic States Hypothyroidism may reduce the requirements for digoxin.
Thyroid Supplement Thyroid Treatment of hypothyroidism in patients taking digoxin may increase the dose requirements of digoxin.
Digoxin responses are normal in patients with compensated thyroid disease.
From the Levothyroxine (Levothyroxine Sodium) label · effective 2024-07-10
Digitalis Glycosides Levothyroxine may reduce the therapeutic effects of digitalis glycosides.
Serum digitalis glycoside levels may be decreased when a hypothyroid patient becomes euthyroid, necessitating an increase in the dose of digitalis glycosides.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.