Digoxin and Piroxicam interaction
Digoxin and Piroxicam: the Piroxicam prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Piroxicam label · effective 2026-07-08
Digoxin: Concomitant use of Piroxicam Capsules can increase serum concentration and prolong half-life of digoxin.
Digoxin Clinical Impact: The concomitant use of piroxicam with digoxin has been reported to increase the serum concentration and prolong the half-life of digoxin.
Intervention: During concomitant use of Piroxicam Capsules and digoxin, monitor serum digoxin levels.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.