Digoxin and Simvastatin interaction
Digoxin and Simvastatin: the Simvastatin prescribing label describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Simvastatin (ZOCOR) label · effective 2025-03-28
Digoxin: During ZOCOR initiation, monitor digoxin levels.
Digoxin Clinical Impact: Concomitant use of digoxin with ZOCOR may result in elevated plasma digoxin concentrations [see Clinical Pharmacology (12.3) ] .
Intervention: Monitor digoxin levels in patients taking digoxin when ZOCOR is initiated.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.