Digoxin and Trazodone interaction
Digoxin and Trazodone: the Trazodone prescribing label describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Trazodone (RALDESY TM) label · effective 2026-09-01
Digoxin or Phenytoin: Monitor for increased digoxin or phenytoin serum levels ( 7 ).
Concomitant use of RALDESY can increase digoxin or phenytoin concentrations.
Continue monitoring and reduce digoxin or phenytoin dose as necessary.
…prolongation or in combination with other drugs that are inhibitors of CYP3A4 (e.g., itraconazole, clarithromycin, voriconazole), or known to prolong QT interval including Class 1A antiarrhythmics (e.g., quinidine, procainamide) or Class 3 antiarrhythmics (e.g., amiodarone, sotalol), certain antipsychotic medications (e.g., ziprasidone, chlorpromazine, thioridazine),…
Digoxin and Phenytoin Clinical Impact: Digoxin and phenytoin are narrow therapeutic index drugs.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.