Diltiazem and Sotalol interaction
Diltiazem and Sotalol: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Diltiazem (Cardizem LA) label · effective 2025-11-11
Concomitant use of diltiazem with beta-blockers or digitalis may result in additive effects on cardiac conduction.
• Beta-blockers, digitalis, and other agents known to impair cardiac contractility and conduction may increase risk for hypotension, bradycardia, and heart failure.
Experience with the use of diltiazem in combination with beta-blockers in patients with impaired ventricular function is limited.
From the Sotalol (Sotalol hydrochloride) label · effective 2025-07-31
Antiarrhythmic and other QT Prolonging Drugs Withdraw other Class I or Class III antiarrhythmic agents prior to dosing with sotalol.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.