Diltiazem and Venlafaxine interaction
Diltiazem and Venlafaxine: the Venlafaxine prescribing label describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Venlafaxine (Venlafaxine Hydrochloride) label · effective 2025-01-31
Metoprolol: Possibly reduced blood-pressure lowering effect despite increased metoprolol plasma levels.
Concomitant use of CYP3A4 inhibitors and venlafaxine may increase levels of venlafaxine and ODV.
Therefore, caution is advised if a patient’s therapy includes a CYP3A4 inhibitor and venlafaxine concomitantly.
Venlafaxine appeared to reduce the blood pressure lowering effect of metoprolol in this study.
CYP3A4 Venlafaxine did not inhibit CYP3A4 in vitro .
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.