Disulfiram and Theophylline interaction

Disulfiram and Theophylline: the Theophylline prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.

Moderate

Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.

What the FDA labels say

From the Theophylline label · effective 2026-01-29

Moderate

Disulfiram Decreases theophylline clearance by inhibiting hydroxylation and demethylation.

Drug interactionsnames DisulfiramView label on DailyMed
Minor

Mexiletine Similar to disulfiram.

Drug interactionsnames DisulfiramView label on DailyMed
Minor

Verapamil Similar to disulfiram.

Drug interactionsnames DisulfiramView label on DailyMed

Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.

Open in the checker

Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.