Dronedarone and Grapefruit interaction
Dronedarone and Grapefruit: the Dronedarone prescribing label flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Dronedarone (Multaq) label · effective 2026-01-27
• Grapefruit juice: Avoid concomitant use.
Grapefruit Juice Patients should avoid grapefruit juice beverages while taking MULTAQ because exposure to dronedarone is significantly increased [see Clinical Pharmacology (12.3) ] .
Curated guidance for Grapefruit
Grapefruit juice changes the amount of these drugs that reaches the bloodstream (raising most, but lowering fexofenadine).
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.