Dronedarone and Ledipasvir and sofosbuvir interaction
Dronedarone and Ledipasvir and sofosbuvir: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Ledipasvir and sofosbuvir label · effective 2025-01-10
Antiarrhythmics: amiodarone Effect on amiodarone, ledipasvir, and sofosbuvir concentrations unknown Coadministration of amiodarone with ledipasvir and sofosbuvir may result in serious symptomatic bradycardia.
From the Dronedarone (Multaq) label · effective 2026-01-27
Follow label recommendations for concomitant use of other statins with a CYP3A and P-gp inhibitor like dronedarone.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.