Dronedarone and Quinidine interaction

Dronedarone and Quinidine: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.

Major

Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.

What the FDA labels say

From the Quinidine (Quinidine Gluconate) label · effective 2024-08-27

Major

Proarrhythmic effects Like many other drugs (including all other Class Ia antiarrhythmics), quinidine prolongs the QT c interval, and this can lead to torsades de pointes , a life-threatening ventricular arrhythmia (see OVERDOSAGE ).

Warningsby drug classView label on DailyMed

From the Dronedarone (Multaq) label · effective 2026-01-27

Minor

Follow label recommendations for concomitant use of other statins with a CYP3A and P-gp inhibitor like dronedarone.

Drug interactionsby drug classView label on DailyMed

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Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.