Emtricitabine, rilpivirine, and tenofovir and St. John's wort interaction
Emtricitabine, rilpivirine, and tenofovir and St. John's wort: the Emtricitabine, rilpivirine, and tenofovir prescribing label flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Emtricitabine, rilpivirine, and tenofovir (COMPLERA) label · effective 2025-07-16
…oxcarbazepine, phenobarbital, phenytoin Antimycobacterials: rifampin, rifapentine Glucocorticoid (systemic): dexamethasone (more than a single-dose) Herbal Products: St John's wort ( Hypericum perforatum ) Proton Pump Inhibitors: e.g., dexlansoprazole, esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole COMPLERA is contraindicated when coadministered…
Herbal Products: St John's wort ( Hypericum perforatum ) ↓ RPV Coadministration is contraindicated due to potential for loss of virologic response and development of resistance.
Curated guidance for St. John's wort
St. John's wort can lower blood levels of some HIV medicines enough to cause treatment failure.
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.