Ethynodiol diacetate and ethinyl estradiol and Fludrocortisone interaction
Ethynodiol diacetate and ethinyl estradiol and Fludrocortisone: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Fludrocortisone (Fludrocortisone Acetate) label · effective 2026-05-06
Estrogen —increased levels of corticosteroid-binding globulin thereby increasing the bound (inactive) fraction; this effect is at least balanced by decreased metabolism of corticosteroids.
When estrogen therapy is initiated, a reduction in corticosteroid dosage may be required, and increased amounts may be required when estrogen is terminated.
From the Ethynodiol diacetate and ethinyl estradiol (Kelnor 1/35) label · effective 2023-02-04
The amount of both steroids should be considered in the choice of an oral contraceptive.
Free T 3 resin uptake is decreased, reflecting the elevated TBG; free T 4 concentration is unaltered. c) Other binding proteins may be elevated in the serum. d) Sex-steroid binding globulins are increased and result in elevated levels of total circulating sex steroids and corticoids; however, free or biologically active levels remain unchanged. e) Triglycerides…
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.