Fluconazole and Nortriptyline interaction
Fluconazole and Nortriptyline: the Fluconazole prescribing label describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Fluconazole label · effective 2026-04-02
Amitriptyline, nortriptyline Fluconazole increases the effect of amitriptyline and nortriptyline.
Dosage of amitriptyline/nortriptyline should be adjusted, if necessary.
5-Nortriptyline and/or S-amitriptyline may be measured at initiation of the combination therapy and after 1 week.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.