Fluvoxamine and Tobacco and smoking interaction

Fluvoxamine and Tobacco and smoking: the Fluvoxamine prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.

Moderate

Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.

What the FDA labels say

From the Fluvoxamine (fluvoxamine maleate) label · effective 2026-04-23

Moderate

Theophylline: The effect of steady-state fluvoxamine (50 mg bid) on the pharmacokinetics of a single dose of theophylline (375 mg as 442 mg aminophylline) was evaluated in 12 healthy non-smoking, male volunteers.

Warnings and precautionsnames Tobacco and smokingView label on DailyMed
Moderate

Effects of Smoking on Fluvoxamine Metabolism Smokers had a 25% increase in the metabolism of fluvoxamine compared to nonsmokers.

Drug interactionsnames Tobacco and smokingView label on DailyMed

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Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.