Norethindrone and ethinyl estradiol and Tobacco and smoking interaction
Norethindrone and ethinyl estradiol and Tobacco and smoking: the Norethindrone and ethinyl estradiol prescribing label flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Norethindrone and ethinyl estradiol (Lo Loestrin Fe) label · effective 2025-03-07
WARNING: CIGARETTE SMOKING AND SERIOUS CARDIOVASCULAR EVENTS Cigarette smoking increases the risk of serious cardiovascular events from combination oral contraceptive (COC ) use.
This risk increases with age , particularly in women over 35 years of age , and with the number of cigarettes smoked .
WARNING : CIGARETTE SMOKING AND SERIOUS CARDIOVASCULAR EVENTS See Full Prescribing Information for complete boxed warning.
Cigarette smoking increases the risk of serious cardiovascular events from combination oral contraceptive (COC ) use ( 4 )
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