Furosemide and Orphenadrine, aspirin, and caffeine interaction
Furosemide and Orphenadrine, aspirin, and caffeine: the Furosemide prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Furosemide label · effective 2026-05-13
• Salicylates : Risk of salicylate toxicity ( 7.1 )
Salicylates May experience salicylate toxicity at lower doses because of competitive renal excretory sites.
Monitor for symptoms of salicylate toxicity.
Indomethacin Coadministration of indomethacin may reduce the natriuretic and antihypertensive effects of furosemide in some patients by inhibiting prostaglandin synthesis.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.