Gabapentin and Probenecid interaction
Gabapentin and Probenecid: the Gabapentin prescribing label mentions this combination without an instruction to avoid it or change the dose.
Mentioned, no instruction to avoid. Worth knowing; rarely a reason to change anything on its own.
What the FDA labels say
From the Gabapentin (Neurontin) label · effective 2026-05-12
Probenecid Probenecid is a blocker of renal tubular secretion.
Gabapentin pharmacokinetic parameters without and with probenecid were comparable.
This indicates that gabapentin does not undergo renal tubular secretion by the pathway that is blocked by probenecid.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.