Glycerol phenylbutyrate and Probenecid interaction
Glycerol phenylbutyrate and Probenecid: the Glycerol phenylbutyrate prescribing label mentions this combination without an instruction to avoid it or change the dose.
Mentioned, no instruction to avoid. Worth knowing; rarely a reason to change anything on its own.
What the FDA labels say
From the Glycerol phenylbutyrate label · effective 2025-06-30
Probenecid : May affect renal excretion of metabolites of glycerol phenylbutyrate, including phenylacetylglutamine (PAGN) and PAA.
Potential for Other Drugs to Affect Glycerol Phenylbutyrate Probenecid Probenecid may inhibit the renal excretion of metabolites of glycerol phenylbutyrate including PAGN and PAA.
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.