Grapefruit and Verapamil interaction
Grapefruit and Verapamil: the Verapamil prescribing label describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Verapamil (Verapamil Hydrochloride) label · effective 2025-03-25
Grapefruit juice may significantly increase verapamil levels ( 7.3 )
Grapefruit Juice Grapefruit juice may significantly increase concentrations of verapamil.
Grapefruit juice given to nine healthy volunteers increased S- and R- verapamil AUC 0-12 by 36% and 28%, respectively.
Steady state C max and C min of S-verapamil increased by 57% and 16.7%, respectively with grapefruit juice compared to control.
Grapefruit juice did not cause a significant difference in the pharmacokinetics of norverapamil.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.